New Treatments for Baldness? Scientists Find Stem Cells That Tell Hair It's Time to Grow

Yale researchers have discovered the source of signals that trigger hair growth, an insight that may lead to new treatments for baldness.

Researchers have discovered the source of signals that trigger hair growth, an insight that may lead to new treatments for baldness. (Credit: © Tasosk / Fotolia)

The researchers identified stem cells within the skin's fatty layer and showed that molecular signals from these cells were necessary to spur hair growth in mice, according to research published in the Sept. 2 issue of the journal Cell.

"If we can get these fat cells in the skin to talk to the dormant stem cells at the base of hair follicles, we might be able to get hair to grow again," said Valerie Horsley, assistant professor of molecular, cellular and developmental biology and senior author of the paper.

Men with male pattern baldness still have stem cells in follicle roots but these stem cells lose the ability to jump-start hair regeneration. Scientists have known that these follicle stem cells need signals from within the skin to grow hair, but the source of those signals has been unclear.

Horsley's team observed that when hair dies, the layer of fat in the scalp that comprises most of the skin's thickness shrinks. When hair growth begins, the fat layer expands in a process called adipogenesis. Researchers found that a type of stem cell involved in creation of new fat cells -- adipose precursor cells -- was required for hair regeneration in mice. They also found these cells produce molecules called PDGF (platelet derived growth factors), which are necessary to produce hair growth.

Horsley's lab is trying to identify other signals produced by adipose precursor stem cells that may play a role in regulating hair growth. She also wants to know whether these same signals are required for human hair growth. Other authors from Yale are lead author Eric Festa, Jackie Fretz, Ryan Berry, Barbara Schmidt, Matthew Rodeheffer and Mark Horowitz.

The work was funded by the National Institutes of Health and the Connecticut Stem Cell Research Program.

Source: ScienceDaily (Sep. 2, 2011)

Comments

Reasons Why Your Hips Hurt

Hips Don't lie Inside the Joint Each hip is a ball-and-socket joint. The ball is the top of your thighbone (femoral head). The socket (acetabulum) is in your pelvic bone. Smooth, slippery tissue called cartilage lets the ball and socket glide against each other when you move. A thin lining (synovium) tops the cartilage and makes a bit of synovial fluid, which further eases rubbing. Tendons, ligaments, and muscles complete the joint. Osteoarthritis It’s the “wear and tear” type of arthritis that many people get in middle age. Cartilage on the ball end of the thighbone and in the hip socket slowly breaks down and causes grinding between bones. You’ll have stiffness, and you might feel pain in your crotch and at the front of your thigh that radiates to your knee and behind. It’s often worse after a hard workout or when you don’t move for a while. Rheumatoid Arthritis With RA, your immune system attacks parts of your body, which can include the syn...

Have Flu-Like Symptoms? Could Be a Semen Allergy

A mysterious syndrome in which men come down with a flu-like illness after an orgasm may be caused by an allergy to semen, Dutch scientists said Monday. Men with the condition, known as post orgasmic illness syndrome or POIS and documented in medical journals since 2002, get flu-like symptoms such as feverishness, runny nose, extreme fatigue and burning eyes immediately after they ejaculate. Symptoms can last for up to week. Marcel Waldinger, a professor of sexual psychopharmacology at Utrecht University in the Netherlands, published two studies which suggest that men with POIS have an allergy to their own semen, and that a treatment known as hyposensitisation therapy can help reduce its impact. "These results are a very important breakthrough in the research of this syndrome," Waldinger said in a telephone interview. He said the findings "contradict the idea that the complaints have a psychological cause" and show that an auto-allergic reaction to semen is th...

New, Noninvasive Paternity Test Developed

Identify the father of a baby as early as the eighth week of pregnancy . The new method, reported in the New England Journal of Medicine , uses fetal DNA isolated from the mother's blood. The test has already been used to prove an affair in a murder trial, and experts say it has other significant medical and legal applications. "The technology is extremely important and really a very, very significant step forward for medical prenatal diagnosis," says Peter Benn, PhD, director of the diagnostic medical genetics laboratories at the University of Connecticut Health Center in Farmington. He was not involved in the research. A previous study by the same researchers showed how the test could be used early in pregnancy to determine whether a fetus has Down syndrome , for example. "That technology will allow genetic disorders to be identified without going through amniocentesis or chorionic villus sampling . That's a very important and useful step forward b...

Life, Health and Enjoyment

Search This Blog